Research
Hormonal
PPARgamma agonists (thiazolidinediones like rosiglitazone) improve insulin sensitivity in obese models by downregulating macrophage-derived inflammatory gene expression in white adipose tissue.
Drugs that activate PPARgamma (like rosiglitazone) work partly by calming inflammation in fat tissue. This suggests that anti-inflammatory strategies might be a valid adjunct to metabolic health management in obesity.
GoodSupportsHIGH confidence
Upon treatment with rosiglitazone, an insulin-sensitizing drug, these macrophage-originated genes are downregulated. ... Our results are consistent with the known anti-inflammation function of TZDs and suggest the possibility that TZDs improve insulin sensitivity at least partially by suppressing the inflammatory events in obese WAT.
Why this rating
Clear experimental evidence showing gene downregulation and reduced macrophage numbers after treatment.
Source
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
Haiyan Xu et al. · Journal of Clinical Investigation · 2003
DOI 10.1172/jci19451
mechanism_onlyCited 5,832×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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