Hormonal
Hypoadiponectinemia (low plasma adiponectin) in obesity and type 2 diabetes is primarily driven by insulin resistance and hyperinsulinemia rather than adiposity (body fat percentage) alone.
If you have low adiponectin, focusing solely on weight loss may not restore levels if insulin resistance persists. Prioritize interventions that improve insulin sensitivity (like resistance training and carbohydrate management) as these are more strongly correlated with healthy adiponectin levels than body fat percentage alone.
These results confirm that obesity and type 2 diabetes are associated with low plasma adiponectin concentrations in different ethnic groups and indicate that the degree of hypoadiponectinemia is more closely related to the degree of insulin resistance and hyperinsulinemia than to the degree of adiposity and glucose intolerance.
Why this rating
Large sample size (n=144), rigorous measurement of insulin sensitivity (hyperinsulinemic clamp), and multivariate analysis controlling for confounders.
Source
Hypoadiponectinemia in Obesity and Type 2 Diabetes: Close Association with Insulin Resistance and Hyperinsulinemia
Christian Weyer et al. · The Journal of Clinical Endocrinology & Metabolism · 2001
DOI 10.1210/jcem.86.5.7463
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