Research
Hormonal
High plasma FFA concentrations impair muscle glycogen synthase (GS) activity, but this impairment occurs late (after 4-6 hours) and is associated with increased glucose-6-phosphate levels.
High levels of fat in your blood can eventually impair the enzyme that helps store glucose as glycogen in your muscles. However, this effect takes several hours to develop and requires high fat levels.
GoodSupportsHIGH confidence
The first consisted of an impairment of muscle glycogen synthase activity. It required high FFA concentration (~750 uM), was associated with an increase in glucose-6-phosphate, and developed after 4-6 h of fat infusion.
Why this rating
Controlled human clinical trial with muscle biopsies.
Source
Mechanisms of fatty acid-induced inhibition of glucose uptake.
G Boden et al. · Journal of Clinical Investigation · 1994
DOI 10.1172/jci117252
rct · n=14Cited 3,473×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Elevated plasma free fatty acid (FFA) concentrations cause a dose-dependent inhibition of insulin-stimulated glucose uptake in skeletal muscle, primarily by reducing glycogen synthesis and secondarily by reducing carbohydrate oxidation.Good
- Elevated plasma free fatty acids (FFA) and/or glycerol increase hepatic glucose output (HGO) by approximately 50%, contributing to hepatic insulin resistance.Good
- Medium plasma FFA concentrations reduce glycogen synthesis by impairing glucose transport or phosphorylation, leading to decreased glucose-6-phosphate levels, before glycogen synthase activity is affected.Good
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