Hormonal
Vitamin D deficiency (serum 25-OH D ≤15 ng/mL) is associated with a significantly increased risk of incident cardiovascular disease, with this association being particularly strong and statistically significant in individuals with hypertension.
If you have high blood pressure, getting your vitamin D levels checked is a prudent step. This study found that low levels (≤15 ng/mL) were linked to a significantly higher risk of heart events in hypertensive individuals. While fixing low levels doesn't guarantee prevention, it may be a valuable part of managing your overall cardiovascular risk, especially given the safety and low cost of supplementation.
Individuals with 25-OH D (≤)15 ng/mL had a multivariable-adjusted hazard ratio of 1.62 (95% confidence interval 1.11 to 2.36, P(≤)0.01) for incident cardiovascular events... This effect was evident in participants with hypertension (hazard ratio 2.13, 95% confidence interval 1.30 to 3.48) but not in those without hypertension (hazard ratio 1.04, 95% confidence interval 0.55 to 1.96).
Why this rating
Prospective cohort study with multivariable adjustment, but observational design cannot prove causation and relies on a single baseline measurement.
Source
Vitamin D Deficiency and Risk of Cardiovascular Disease
Thomas J. Wang et al. · Circulation · 2008
DOI 10.1161/circulationaha.107.706127
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