Research
Hormonal
Insulin resistance directly causes cardiovascular disease through three primary mechanisms: signal transduction alteration, impaired substrate metabolism regulation, and altered substrate delivery to the myocardium.
If you have insulin resistance (often associated with obesity or type 2 diabetes), you are at higher risk for heart disease regardless of your cholesterol levels. Addressing insulin sensitivity through lifestyle changes is critical for heart health.
GoodSupportsHIGH confidence
it can be concluded that insulin resistance in the myocardium generates damage by at least three different mechanisms: (1) signal transduction alteration, (2) impaired regulation of substrate metabolism, and (3) altered delivery of substrates to the myocardium.
Why this rating
Based on a comprehensive review of multiple studies and meta-analyses cited in the text.
Source
Association between insulin resistance and the development of cardiovascular disease
Valeska Ormazábal et al. · Cardiovascular Diabetology · 2018
DOI 10.1186/s12933-018-0762-4
narrative_reviewCited 2,367×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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