Research
Hormonal
AdipoQ (adiponectin) mRNA expression is significantly down-regulated in adipose tissue from obese humans and obese mice compared to lean controls.
This paper identifies that adiponectin (AdipoQ) levels drop significantly in obesity. While this paper does not offer a treatment, it establishes that obesity is associated with a specific hormonal deficit, suggesting that restoring these levels might be a therapeutic target.
GoodRefutesHIGH confidence
a significant reduction in adipoQ mRNA expression was observed in fat tissue from the obese mice... A reduction of 50 – 80% in adipoQ mRNA was observed in obese human fat tissue samples... Thus, expression of adipoQ mRNA is clearly dysregulated in obesity of both mouse and humans.
Why this rating
Strong observational evidence in both murine models (ob/ob) and human subjects (BMI > 39 vs 21), though functional consequences were not yet defined.
Source
AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity
Erding Hu et al. · Journal of Biological Chemistry · 1996
DOI 10.1074/jbc.271.18.10697
mechanism_onlyCited 2,257×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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