Hormonal
The transcription factor mPPAR gamma 2 (PPAR-gamma 2) functions as a tissue-specific regulator that, when heterodimerized with RXR alpha, activates the adipocyte-specific aP2 enhancer to drive adipocyte differentiation and gene expression.
This paper identifies PPAR-gamma 2 as a master switch for fat cell identity. While it doesn't prescribe a diet, it explains why fat cells are distinct from other cells and how they respond to fatty acids and specific drugs (like thiazolidinediones, implied by 'peroxisome proliferators'). For health, this underscores that fat is biologically active and regulated by specific molecular pathways.
We have cloned a novel member of the peroxisome proliferator-activated receptor family designated mPPAR gamma 2, and we demonstrate that a heterodimeric complex of mPPAR gamma 2 and RXR alpha constitute a functional ARF6 complex... forced expression of mPPAR gamma 2 and RXR alpha activates the adipocyte-specific aP2 enhancer in cultured fibroblasts.
Why this rating
Strong molecular biology evidence (cloning, binding assays, transfection) but limited to cell culture and transgenic models, not human clinical outcomes.
Source
mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.
Peter Tontonoz et al. · Genes & Development · 1994
DOI 10.1101/gad.8.10.1224
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