Research
Hormonal
Long-term stable use of GLP-1 receptor agonists results in attenuated gastric emptying effects (tachyphylaxis) compared to recent initiation, reducing perioperative risk.
If you have been on your GLP-1 shot for months, your body has likely adapted, and your stomach empties more normally than when you first started. This makes surgery safer for you than for someone who just started the drug two weeks ago.
GoodSupportsMEDIUM confidence
Adherence to long-term stable GLP-1 RA therapy appears to result in less delay in gastric emptying compared to patients who have recently started the therapy.
Why this rating
Based on scintigraphy studies and observational data comparing recent vs. long-term users.
Source
Perioperative Management of GLP-1 Receptor Agonists: Balancing Aspiration Risk with Therapeutic Benefit
Enoch Chi Ngai Lim et al. · SN Comprehensive Clinical Medicine · 2025
DOI 10.1007/s42399-025-02079-9
narrative_reviewCited 5×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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