Hormonal
Women with polycystic ovary syndrome (PCO) exhibit profound peripheral insulin resistance that is independent of obesity, body composition, and glucose tolerance status.
If you have PCO, you likely have insulin resistance regardless of your weight. This is not just a 'weight problem' but a hormonal one. Focus on managing insulin sensitivity through diet and lifestyle, as standard weight-loss advice alone may not address the underlying resistance inherent to the syndrome.
We conclude that 1) PCO women have significant insulin resistance that is independent of obesity, changes in body composition, and impairment of glucose tolerance...
Why this rating
High-quality evidence using the gold-standard euglycemic glucose-clamp technique with rigorous matching for body composition.
Source
Profound Peripheral Insulin Resistance, Independent of Obesity, in Polycystic Ovary Syndrome
Andrea Dunaif et al. · Diabetes · 1989
DOI 10.2337/diab.38.9.1165
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