Hormonal
Subcutaneous semaglutide at 0.4 mg daily significantly improves histologic resolution of NASH without worsening fibrosis in patients with stage F2 or F3 fibrosis compared to placebo.
For patients with NASH and fibrosis stages F2 or F3, treatment with 0.4 mg of subcutaneous semaglutide daily for 72 weeks significantly increases the likelihood of NASH resolution without worsening fibrosis compared to placebo. This benefit comes with a higher risk of gastrointestinal side effects, particularly nausea, which often diminishes over time. Patients should be counseled on nutrition and physical activity alongside this treatment.
The percentage of patients in whom NASH resolution was achieved with no worsening of fibrosis was 40% in the 0.1-mg group, 36% in the 0.2-mg group, 59% in the 0.4-mg group, and 17% in the placebo group (P<0.001 for semaglutide 0.4 mg vs. placebo).
Why this rating
Phase 2, randomized, double-blind, placebo-controlled trial with 320 patients.
Source
A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis
Philip N. Newsome et al. · New England Journal of Medicine · 2020
DOI 10.1056/nejmoa2028395
More from this paper
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →