Hormonal
Intensive glycemic therapy in Type 1 Diabetes produces a 'metabolic memory' effect, where the initial intensive treatment continues to reduce the risk of complications for years even after glycemic separation between treatment groups disappears.
Even if your blood sugar levels aren't perfect now, getting them under control early in your Type 1 Diabetes journey has long-lasting benefits. This 'metabolic memory' means that your body continues to benefit from early intensive treatment, reducing your risk of heart disease and other complications for decades, even if your glucose levels later become less distinct from those who had less intensive treatment.
EDIC showed a durable effect of initial assigned therapies despite a loss of the glycemic separation (metabolic memory) and demonstrated that the reduction in early-stage complications during the DCCT translated into substantial reductions in severe complications and CVD.
Why this rating
Based on the same high-quality DCCT/EDIC data.
Source
The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study at 30 Years: Overview
David M. Nathan · Diabetes Care · 2013
DOI 10.2337/dc13-2112
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