Research
Hormonal
Endogenous GLP-1 is primarily secreted by intestinal L-cells in response to nutrient contact, not by pancreatic alpha-cells.
Your body naturally produces GLP-1 from your intestines when you eat. This hormone helps regulate blood sugar and appetite. Dietary fiber and nutrients stimulate this natural release.
StrongSupportsVERY_HIGH confidence
Intestinal proglucagon is cleaved into distinct fractions that are different from those derived in the pancreas... GLP-1 released from intestinal L-cells have opposing effects on blood glucose [to glucagon].
Why this rating
Well-established physiological fact reviewed in detail.
Source
Glucagon-like peptide 1 (GLP-1)
Timo D. Müller et al. · Molecular Metabolism · 2019
DOI 10.1016/j.molmet.2019.09.010
narrative_reviewCited 1,709×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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