Research
Hormonal
Bile acids regulate energy expenditure through a pathway independent of FXR, mediated by the G-protein coupled receptor TGR5.
TGR5 activation by bile acids contributes to energy expenditure. This highlights the importance of gut health and bile acid composition for metabolic rate, independent of just fat digestion.
GoodSupportsHIGH confidence
BA may regulate energy expenditure in a FXR-independent manner in mice, via activation of the G protein-coupled receptor TGR5.
Why this rating
Based on recent reports cited in the review regarding TGR5's role.
Source
Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation
Philippe Lefèbvre et al. · Physiological Reviews · 2009
DOI 10.1152/physrev.00010.2008
narrative_reviewCited 1,634×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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