Research
Hormonal
An AST/ALT ratio greater than 1 is an independent predictor of severe liver fibrosis (bridging fibrosis or cirrhosis) in NASH patients, independent of age, obesity, and diabetes.
Ask your doctor about your AST/ALT ratio. In NASH, a ratio greater than 1 is a warning sign of potential severe scarring, even if your individual enzyme levels appear only mildly elevated. This marker helps identify who needs closer monitoring or biopsy.
GoodSupportsHIGH confidence
In multivariate analysis, older age (P < .001), obesity (P < .002), diabetes mellitus (P < .009), and aspartate transaminase/alanine transaminase (AST/ALT) ratio greater than 1 (P < .03) were significant predictors of severe liver fibrosis (bridging/cirrhosis).
Why this rating
Statistically significant in multivariate analysis.
Source
Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis
Paul Angulo et al. · Hepatology · 1999
DOI 10.1002/hep.510300604
cohort · n=144Cited 1,609×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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