Research
Hormonal
Inhibiting Gs signaling specifically in K cells reduces plasma GIP levels and worsens glucose tolerance after refeeding.
This finding highlights that the natural Gs-mediated signaling in gut K cells is essential for maintaining normal blood sugar levels after eating. Disrupting this specific pathway impairs the body's ability to manage glucose spikes.
GoodSupportsHIGH confidence
K cell–specific Gnas-KO mice displayed markedly reduced plasma GIP levels... the K-Gs–KO mice showed a modest but significant increase in blood glucose levels as compared with their control littermates
Why this rating
High-quality mechanistic evidence using knockout mouse models.
Source
Activation of Gs signaling in mouse enteroendocrine K cells greatly improves obesity- and diabetes-related metabolic deficits
Antwi‐Boasiako Oteng et al. · Journal of Clinical Investigation · 2024
DOI 10.1172/jci182325
mechanism_onlyCited 5×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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