Research
Hormonal
Letrozole is the first-line pharmacological therapy for infertility in women with PCOS, superior to or preferred over Clomiphene and Metformin.
If you are trying to conceive, Letrozole is the recommended first medication. Clomiphene and Metformin are used if Letrozole is not suitable or effective.
GoodSupportsHIGH confidence
Letrozole is first-line pharmacological infertility therapy; with clomiphene and metformin both having a role, alone and in combination.
Why this rating
Supported by evidence-based recommendations (EBR) with strong GRADE (****).
Source
Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome†‡
Helena Teede et al. · Human Reproduction · 2018
DOI 10.1093/humrep/dey256
clinical_guidelineCited 1,549×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Combined oral contraceptive pills (COCP) are the first-line pharmacological management for menstrual irregularity and hyperandrogenism in women with PCOS.Good
- Lifestyle modification, specifically education, self-empowerment, and weight management, is the prioritized first-line intervention for the prevention and management of excess weight in women with PCOS.Moderate
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