Research
Hormonal
Obesity increases the risk of type 2 diabetes mellitus in a curvilinear manner, with relative risk increasing 40-fold at a BMI of 35 kg/m2 compared to a BMI of 22 kg/m2.
Maintaining a healthy body weight is the most effective way to prevent type 2 diabetes. The risk of developing diabetes increases dramatically as your BMI rises, especially above 35 kg/m2. Losing even a modest amount of weight (5-11 kg) can significantly reduce your risk.
StrongSupportsVERY_HIGH confidence
As BMI increased, the relative risk increased, such that at a BMI of 35 kg/m2, the relative risk increased 40-fold, or 4000%.
Why this rating
Based on large prospective cohort studies (Nurses Health Study, Health Professionals Follow-Up Study).
Source
Medical Consequences of Obesity
George A. Bray · The Journal of Clinical Endocrinology & Metabolism · 2004
narrative_reviewCited 1,539×
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