Research
Macro partitioning
High intake of trans-fatty acids significantly increases the risk of coronary heart disease and cardiac arrest, independent of saturated fat intake, by raising LDL-C, lowering HDL-C, and promoting insulin resistance.
Avoid foods with 'partially hydrogenated oils' on the ingredient list. These trans-fats are twice as harmful to your cholesterol levels as saturated fats. Replace them with natural oils like olive or canola oil.
StrongSupportsHIGH confidence
In numerous controlled metabolic studies, trans-fatty acids... have been shown to raise LDL-C levels and lower HDL-C relative to cis-unsaturated fatty acids... The increase in the ratio of total to HDL cholesterol for trans-fat is approximately twice that for saturated fat.
Why this rating
Supported by multiple prospective cohort studies, metabolic studies, and case-control studies.
Source
Optimal Diets for Prevention of Coronary Heart Disease
Frank B. Hu · JAMA · 2002
narrative_reviewCited 1,509×
Read the paper This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →