Research
Hormonal
Genetic mutations in the insulin receptor gene cause rare, severe forms of insulin resistance (e.g., leprechaunism), but these mutations are not observed in routine type-2 diabetes.
Unlike rare genetic disorders, common type-2 diabetes is not caused by broken insulin receptor genes. It is a functional problem of how cells respond to insulin, driven by lifestyle and metabolic factors.
StrongRefutesHIGH confidence
Insulin receptor mutations have not been observed in patients with routine type-2 diabetes (T2D).
Why this rating
Clear distinction made in the review between rare genetic syndromes and common T2D.
Source
Insulin Receptor Signaling in Normal and Insulin-Resistant States
Jérémie Boucher et al. · Cold Spring Harbor Perspectives in Biology · 2014
DOI 10.1101/cshperspect.a009191
narrative_reviewCited 1,452×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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