Research
Hormonal
Subcutaneous recombinant leptin administration induces a dose-dependent reduction in body weight and fat mass in both lean and obese adults, with the majority of weight loss attributable to fat loss.
Daily subcutaneous injections of recombinant leptin can lead to significant fat loss in both lean and obese adults, with higher doses producing greater weight reduction. While the treatment is effective, it requires daily injections and may cause local skin reactions, though these are typically manageable.
GoodSupportsHIGH confidence
A dose-response relationship with weight and fat loss was observed with subcutaneous recombinant leptin injections in both lean and obese subjects... more than 95% of weight loss was fat loss in the 2 highest dose cohorts at 24 weeks.
Why this rating
Randomized, double-blind, placebo-controlled trial with dose escalation, though limited by short duration and high dropout in high-dose groups.
Source
Recombinant Leptin for Weight Loss in Obese and Lean Adults
Steven B. Heymsfield et al. · JAMA · 1999
DOI 10.1001/jama.282.16.1568
rct · n=127Cited 1,425×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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