Research
Hormonal
Metformin is the first-line pharmacological treatment for T2DM and prediabetes, offering significant reduction in microvascular complications and diabetes-related deaths through mechanisms including inhibition of hepatic gluconeogenesis and increased insulin sensitivity.
Metformin is the standard first-line drug for T2DM and prediabetes. It reduces complications and deaths. If you experience stomach upset, ask your doctor about slow-release versions or slow titration to manage side effects.
StrongSupportsVERY_HIGH confidence
It is the first drug recommended by all guidelines for the treatment of T2DM and the prevention of overt diabetes among the high-risk prediabetes population [49].
Why this rating
Supported by UKPDS, 10-year follow-up, and meta-analyses cited.
Source
Management of Type 2 Diabetes Mellitus
Leslie Bahn Kawa · IntechOpen eBooks · 2023
book_chapterCited 5×
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