Research

Hormonal

Metformin is the first-line pharmacological treatment for T2DM and prediabetes, offering significant reduction in microvascular complications and diabetes-related deaths through mechanisms including inhibition of hepatic gluconeogenesis and increased insulin sensitivity.

Metformin is the standard first-line drug for T2DM and prediabetes. It reduces complications and deaths. If you experience stomach upset, ask your doctor about slow-release versions or slow titration to manage side effects.

StrongSupportsVERY_HIGH confidence
It is the first drug recommended by all guidelines for the treatment of T2DM and the prevention of overt diabetes among the high-risk prediabetes population [49].
Leslie Bahn Kawa · IntechOpen eBooks · 2023

Why this rating

Supported by UKPDS, 10-year follow-up, and meta-analyses cited.

Source

Management of Type 2 Diabetes Mellitus

Leslie Bahn Kawa · IntechOpen eBooks · 2023

book_chapterCited 5×
Read the paper

This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →