Hormonal
Exenatide (5-10 mcg twice daily) significantly improves glycemic control (HbA1c reduction of 0.46-0.86%) and promotes progressive weight loss in type 2 diabetes patients failing sulfonylurea monotherapy, without causing severe hypoglycemia.
If you have type 2 diabetes and your current sulfonylurea medication isn't controlling your blood sugar well, adding exenatide (a once- or twice-daily injection) can significantly lower your HbA1c and help you lose weight. While you might experience some nausea or mild hypoglycemia initially, these side effects often decrease over time, and the medication does not cause severe hypoglycemia on its own. It is a viable option for improving glycemic control when other treatments fail.
At week 30, HbA1c changes from baseline were -0.86 ± 0.11, -0.46 ± 0.12, and 0.12 ± 0.09%... in the 10-µg, 5-µg, and placebo arms, respectively... Subjects in the exenatide arms had dose-dependent progressive weight loss, with an end-of-study loss in the 10-µg exenatide arm of -1.6 ± 0.3 kg from baseline... No severe hypoglycemia was observed.
Why this rating
Triple-blind, placebo-controlled, randomized clinical trial with a large sample size (n=377) and rigorous statistical analysis.
Source
Effects of Exenatide (Exendin-4) on Glycemic Control Over 30 Weeks in Sulfonylurea-Treated Patients With Type 2 Diabetes
John B. Buse et al. · Diabetes Care · 2004
DOI 10.2337/diacare.27.11.2628
Related findings · Hormonal
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