Research
Hormonal
Elevated plasma free fatty acids blunt insulin-stimulated IRS-1–associated phosphatidylinositol 3-kinase (PI 3-kinase) activity in skeletal muscle.
High circulating fats prevent insulin from activating a key enzyme (PI 3-kinase) required for glucose uptake. This molecular blockage is a primary reason why high fat states lead to insulin resistance.
GoodSupportsHIGH confidence
Insulin stimulation, during the glycerol infusion, resulted in a fourfold increase in PI 3-kinase activity over basal that was abolished during the lipid infusion.
Why this rating
Direct measurement in human muscle biopsies using rigorous biochemical assays.
Source
Effects of free fatty acids on glucose transport and IRS-1–associated phosphatidylinositol 3-kinase activity
Alan Dresner et al. · Journal of Clinical Investigation · 1999
DOI 10.1172/jci5001
crossover · n=14Cited 1,308×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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