Hormonal
FTO-mediated demethylation of N6-methyladenosine (m6A) on mRNA regulates alternative splicing of adipogenic factors (specifically RUNX1T1) and is required for adipogenesis.
This research explains the biological basis of fat cell formation. While you cannot directly control FTO or m6A levels with a simple supplement, understanding that fat cells must actively differentiate helps explain why weight loss is difficult once fat cells are established. Maintaining a healthy weight prevents the need for new fat cell formation.
FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis
Why this rating
High-quality in vitro and in vivo molecular biology evidence (siRNA, knockout, sequencing).
Source
FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis
Xu Zhao et al. · Cell Research · 2014
DOI 10.1038/cr.2014.151
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