Research
Hormonal
Glucagon-like peptide-1 (GLP-1) receptor agonists, such as exenatide, promote progressive weight loss in humans over up to two years while improving glycemic control, distinguishing them from other diabetes treatments that often cause weight gain.
GLP-1 receptor agonists are a highly effective treatment for both diabetes and obesity. They work by mimicking a gut hormone that signals fullness to the brain. Unlike many other diabetes drugs, they help patients lose weight progressively over time.
StrongSupportsVERY_HIGH confidence
patients with diabetes treated with either GLP1 or the GLP1 receptor (GLP1R) agonist exenatide lose weight progressively in trials lasting up to two years.
Why this rating
Cited clinical trials show progressive weight loss over two years.
Source
Gastrointestinal regulation of food intake
David E. Cummings et al. · Journal of Clinical Investigation · 2007
DOI 10.1172/jci30227
narrative_reviewCited 1,196×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Gastrointestinal satiation signals, specifically cholecystokinin (CCK), glucagon-like peptide-1 (GLP-1), and peptide YY (PYY), regulate meal termination and size through neural and hormonal pathways to the hindbrain, acting synergistically with gastric distention.Strong
- Pharmacological administration of cholecystokinin (CCK) reduces meal size acutely in humans and animals, but chronic administration fails to produce sustained weight loss due to compensatory increases in meal frequency.Good
- Ghrelin is the only known hormone that powerfully increases food intake, with levels surging before meals and suppressing after eating, playing a key role in meal initiation and hunger.Good
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