Research
Mixed
Embryonic skeletal muscle formation is primarily driven by extrinsic morphogen gradients (Wnt, Shh, BMP) that pattern the somite and regulate intrinsic transcription factors (Pax3, MyoD, Myf5), whereas adult muscle regeneration relies on the activation of quiescent satellite cells that reuse this same genetic hierarchy.
Understanding muscle biology requires recognizing that muscle growth and repair are governed by complex genetic and signaling pathways. While resistance training stimulates these pathways, the underlying biological machinery for creating and maintaining muscle tissue is deeply rooted in developmental processes that remain active in adults via satellite cells.
StrongSupportsHIGH confidence
An elaborate interplay of extrinsic and intrinsic regulatory mechanisms controls myogenesis at all stages of development... Adult skeletal muscle... relies on a mechanism that compensates for the turnover of terminally differentiated cells... This type of myogenesis depends on the activation of satellite cells that have the potential to differentiate into new fibers.
Why this rating
High-quality review of genetic studies, knockout mice, and molecular pathways.
Source
Building Muscle: Molecular Regulation of Myogenesis
C. Florian Bentzinger et al. · Cold Spring Harbor Perspectives in Biology · 2012
narrative_reviewCited 1,178×
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