Hormonal
Body weight reduction significantly increases plasma levels of the anti-inflammatory protein adiponectin, with the magnitude of increase correlating with reductions in BMI and hip circumference.
For severely obese individuals, significant weight loss (whether through surgery or other means) triggers a beneficial hormonal response by increasing adiponectin, an anti-inflammatory protein. This suggests that reducing fat mass actively improves metabolic health by removing the 'brakes' on this protective hormone, potentially lowering cardiovascular risk.
In conclusion, body weight reduction increased the plasma levels of a protective adipocytokine, adiponectin.
Why this rating
Randomized controlled trial design (pre-post intervention with surgery) with statistically significant correlations, though small sample size (n=22).
Source
Weight Reduction Increases Plasma Levels of an Adipose-Derived Anti-Inflammatory Protein, Adiponectin
Wei‐Shiung Yang et al. · The Journal of Clinical Endocrinology & Metabolism · 2001
DOI 10.1210/jcem.86.8.7741
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