Research
Hormonal
Exercise-induced myokines, including IL-6, IL-15, and FSTL1, mediate muscle-bone, muscle-skin, and muscle-vascular crosstalk, promoting bone formation, skin health, and cardiovascular protection.
Regular exercise helps maintain strong bones and healthy skin by triggering your muscles to release factors like IGF-1 and IL-15. These signals support bone formation and skin structure, contributing to overall long-term health and vitality.
ModerateSupportsMEDIUM confidence
Muscle-derived IGF-1 can act on local osteoblasts that express the IGF-1Receptor and thereby promote bone formation... Tarnopolsky and colleagues demonstrated that endurance exercise improves age-associated skin changes... The study supports the idea that exercise retards skin aging via a mechanism that involves muscle-derived IL-15... FSTL1 has been shown to possess cardioprotective effects, promoting endothelial cell function and nitric-oxide synthase.
Why this rating
Supported by rodent models and some human observational data, but less direct human intervention evidence compared to metabolic effects.
Source
Muscle–Organ Crosstalk: The Emerging Roles of Myokines
Mai Charlotte Krogh Severinsen et al. · Endocrine Reviews · 2020
DOI 10.1210/endrev/bnaa016
narrative_reviewCited 1,092×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Exercise-induced skeletal muscle secretion of IL-6 mediates metabolic crosstalk, specifically enhancing glucose uptake and fatty acid oxidation within muscle and stimulating hepatic glucose production during exercise.Good
- Exercise-induced secretion of myokines like IL-6, BDNF, Cathepsin B, and Irisin mediates muscle-brain crosstalk, promoting hippocampal neurogenesis, cognitive function, and potentially protecting against neurodegenerative diseases.Good
- Exercise-induced myokines, particularly IL-6, mediate muscle-adipose crosstalk by promoting lipolysis, fat oxidation, and potentially the browning of white adipose tissue, thereby reducing visceral adiposity.Good
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