Research
Macro partitioning
A low-fat dietary intervention significantly reduces LDL cholesterol, diastolic blood pressure, and Factor VIIc levels, but does not significantly affect HDL cholesterol, triglycerides, glucose, or insulin levels.
If you follow a low-fat diet, you can expect a modest drop in LDL cholesterol and blood pressure. However, do not expect significant improvements in HDL cholesterol, triglycerides, or blood sugar control from this dietary pattern alone.
StrongQualifiesHIGH confidence
Low-density lipoprotein cholesterol levels, diastolic blood pressure, and factor VIIc levels were significantly reduced by 3.55 mg/dL, 0.31 mm Hg, and 4.29%, respectively; levels of high-density lipoprotein cholesterol, triglycerides, glucose, and insulin did not significantly differ in the intervention vs comparison groups.
Why this rating
Derived from the same high-quality RCT with a subsample of biomarkers.
Source
Low-Fat Dietary Pattern and Risk of Cardiovascular Disease
Barbara V. Howard et al. · JAMA · 2006
DOI 10.1001/jama.295.6.655
rct · n=48835Cited 1,089×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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