Research
Macro partitioning
Among women who achieved the lowest intakes of saturated fat (<6.1% energy) or trans fat (<1.1% energy), or highest intakes of vegetables and fruits (>=6.5 servings/day), there was a trend toward reduced CHD risk, although it did not reach statistical significance after adjustment for confounders.
While the overall low-fat diet didn't prevent heart disease, focusing specifically on minimizing saturated and trans fats, and maximizing vegetable and fruit intake, may offer some protective benefit against coronary heart disease.
GoodQualifiesMEDIUM confidence
Trends toward greater reductions in CHD risk were observed in those with lower intakes of saturated fat or trans fat or higher intakes of vegetables/fruits.
Why this rating
Exploratory analysis with trends that did not reach statistical significance after adjustment; subject to residual confounding.
Source
Low-Fat Dietary Pattern and Risk of Cardiovascular Disease
Barbara V. Howard et al. · JAMA · 2006
DOI 10.1001/jama.295.6.655
rct · n=48835Cited 1,089×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- A long-term dietary intervention reducing total fat to 20% of calories and increasing fruits, vegetables, and grains does not significantly reduce the risk of coronary heart disease, stroke, or composite cardiovascular disease in postmenopausal women.Strong
- A low-fat dietary intervention significantly reduces LDL cholesterol, diastolic blood pressure, and Factor VIIc levels, but does not significantly affect HDL cholesterol, triglycerides, glucose, or insulin levels.Strong
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