Hormonal
Exposure to Metabolism Disrupting Chemicals (MDCs) during critical developmental periods increases susceptibility to metabolic diseases (obesity, T2D, NAFLD) by altering the physiological set point, requiring a secondary environmental hit (e.g., high-fat diet) for disease manifestation.
To reduce your risk of metabolic disorders, minimize exposure to endocrine-disrupting chemicals (MDCs) found in consumer products, especially during pregnancy and childhood. This involves choosing fresh foods over canned (BPA), avoiding plastic containers for hot foods, and filtering water, as these exposures can permanently alter your body's metabolic set point.
While some MDCs can actually cause metabolic diseases per se many act via increasing the sensitivity or susceptibility to disease (e.g. alter set point for disease) and require a “second hit” later in life like high fat diet or lack of exercise.
Why this rating
The paper is a comprehensive review citing extensive animal models and human epidemiological data, though direct human causal proof is often inferred from animal data.
Source
Metabolism disrupting chemicals and metabolic disorders
Jerrold J. Heindel et al. · Reproductive Toxicology · 2016
DOI 10.1016/j.reprotox.2016.10.001
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