Research
Hormonal
Caloric restriction (CR) and impaired Insulin/IGF-1 signaling (IIS) extend lifespan by improving mitochondrial function and metabolism, rather than by reducing oxidative damage.
Reducing caloric intake (without malnutrition) and maintaining healthy insulin sensitivity appear to activate pathways (like SIRT1 and AMPK) that improve mitochondrial health and extend lifespan. This suggests that metabolic health is more important than just calorie counting for longevity.
GoodSupportsHIGH confidence
current findings suggest that the beneficial effect of CR on longevity is at least partly mediated by improved mitochondrial function mediated through activation of SIRT1 and PGC-1α.
Why this rating
Supported by multiple studies in worms, flies, and mammals, though the exact mechanisms in humans are noted as needing further study.
Source
The role of mitochondria in aging
Ana Bratić et al. · Journal of Clinical Investigation · 2013
DOI 10.1172/jci64125
narrative_reviewCited 1,075×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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