Hormonal
Genetic variants near the NKX6.3 gene (specifically rs6981587) are associated with the degree of weight loss in response to low-caloric diet interventions, with the major C allele linked to decreased weight loss efficacy.
If you are struggling with weight loss despite strict adherence to a low-calorie diet, genetic factors near the NKX6.3 gene may be influencing your response. This is not a failure of willpower but a biological variance. Consider genetic counseling or personalized nutrition approaches that account for this variability, rather than assuming standard protocols will work identically for everyone.
Interestingly, the major allele (C) for rs6981587, near MIR486/NKX6.3, was associated with decreased weight loss.
Why this rating
Strong human GWAS replication across two large cohorts (n=1166 and n=789) combined with functional validation in Drosophila, though human tissue-specific mechanistic proof is still emerging.
Source
Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism
Armand Valsesia et al. · Nature Communications · 2019
DOI 10.1038/s41467-019-08492-8
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