Research
Hormonal
Pasteurization of Akkermansia muciniphila enhances its metabolic benefits compared to live administration, likely due to the exposure of outer membrane proteins like Amuc_1100.
If you take Akkermansia muciniphila, a pasteurized (heat-treated) version may be more effective than a live one. The heat process exposes specific proteins (Amuc_1100) that boost metabolic health. This form is also more stable for storage.
ModerateSupportsMEDIUM confidence
Unexpectedly, this method of inactivation did not abolish the effect of A. muciniphila but even exacerbated its beneficial impact... A potential mechanism explaining this could be the exposure of active molecules by the heat treatments, including Amuc_1100, or the inactivation of inhibitory compounds, or combinations thereof.
Why this rating
Strong preclinical data; human safety data exists, but efficacy data for pasteurized form in humans is not yet fully reported in this review (only safety).
Source
Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila
Patrice D. Cani et al. · Frontiers in Microbiology · 2017
DOI 10.3389/fmicb.2017.01765
narrative_reviewCited 1,058×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- A specific outer membrane protein from Akkermansia muciniphila, Amuc_1100, mediates the metabolic benefits by activating Toll-Like Receptor 2 (TLR2).Good
- Daily oral administration of live Akkermansia muciniphila (2.10^8 cells) improves metabolic health in high-fat diet-fed mice by restoring gut barrier function and reducing metabolic endotoxemia.Moderate
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