Research
Hormonal
Acute elevation of free fatty acids (FFA) significantly inhibits insulin-stimulated glucose uptake in peripheral tissues (muscle) in healthy humans, regardless of blood glucose levels.
If you are healthy and insulin-sensitive, eating a high-fat meal will temporarily make your body less efficient at clearing glucose from your blood. This is due to the 'Randle cycle' where fat oxidation competes with glucose usage. This effect is reversed when insulin levels are low (fasting state).
GoodSupportsHIGH confidence
With euglycemic hyperinsulinemia (study A), lipid infusion caused a significant inhibition of total glucose uptake (6.3±1.3 vs. 7.4±0.6 mg/min.kg, P < 0.02)... With hyperglycemic hyperinsulinemia (study B), lipid infusion also induced a marked impairment in glucose utilization (6.2±1.1 vs. 9.8±1.9 mg/min kg, P < 0.05)
Why this rating
Controlled human clinical trials with rigorous clamping techniques.
Source
Effect of fatty acids on glucose production and utilization in man.
Eleuterio Ferrannini et al. · Journal of Clinical Investigation · 1983
DOI 10.1172/jci111133
rct · n=26Cited 1,057×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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