Research
Hormonal
Ectopic expression of the transcription factor ADD1 (SREBP1) promotes adipocyte differentiation and activates gene expression linked to fatty acid metabolism (specifically FAS and LPL).
This paper describes a fundamental biological mechanism of fat cell formation. It does not provide a direct lifestyle or supplement intervention for humans, but establishes that ADD1/SREBP1 is a key regulator of fat metabolism and differentiation.
GoodSupportsHIGH confidence
These data indicate that ADD1 plays an important role in fat cell gene expression and differentiation, and suggest that it may function by augmenting a step in PPAR-gamma-mediated transcription.
Why this rating
Strong in vitro evidence using retroviral vectors in cell lines, though not a clinical trial.
Source
ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism.
Jae Bum Kim et al. · Genes & Development · 1996
DOI 10.1101/gad.10.9.1096
mechanism_onlyCited 1,041×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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