Research
Hormonal
African-American youth exhibit greater insulin responses during glucose tolerance testing and hyperglycemic clamp studies compared to white youth, indicating reduced insulin sensitivity.
African-American youth may have a higher baseline risk for insulin resistance. Regular screening and lifestyle interventions focusing on insulin sensitivity (diet, exercise) are important.
GoodSupportsHIGH confidence
African-American children and youth have greater insulin responses during glucose tolerance testing and during hyperglycemic clamp study than do whites.
Why this rating
Based on specific studies (Bogalusa Heart Study) cited.
Source
Emerging epidemic of type 2 diabetes in youth.
Arlan L. Rosenbloom et al. · Diabetes Care · 1999
DOI 10.2337/diacare.22.2.345
narrative_reviewCited 1,027×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Type 2 diabetes incidence in youth is increasing rapidly and is strongly associated with obesity, particularly in minority populations (Native American, African-American, Mexican-American, Japanese).Strong
- Poor fetal and infant nutrition (low birth weight) increases the risk of developing Type 2 diabetes in adulthood, likely through programmed insulin resistance and beta-cell dysfunction.Good
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →