Hormonal
Decreasing TOR pathway signaling in yeast extends chronological life span by inducing a starvation response that increases stress resistance and storage carbohydrate accumulation.
This research in yeast suggests that limiting nutrient availability, specifically amino acids, triggers a survival mechanism (reduced TOR signaling) that extends life by boosting stress resistance. While this is a model organism study, it supports the human health principle that calorie restriction or specific nutrient limitations may promote longevity through conserved biological pathways.
We propose that up-regulation of a highly conserved response to starvation-induced stress is important for life span extension by decreased TOR signaling in yeast and higher eukaryotes.
Why this rating
High-quality experimental data using genome-wide screens, pharmacological inhibition, and genetic deletions in a controlled model organism.
Source
Extension of chronological life span in yeast by decreased TOR pathway signaling
Ryan Powers et al. · Genes & Development · 2006
DOI 10.1101/gad.1381406
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