Hormonal
Homozygosity for the minor G allele of the FOXO3A gene (rs2802292) is strongly associated with increased human longevity, conferring approximately twice the protective effect (OR 2.75) compared to the major TT allele.
You cannot change your FOXO3A genotype, but this research highlights that the genetic variants associated with longevity are also linked to better insulin sensitivity and lower risk of chronic diseases like heart disease and cancer. Focus on maintaining high insulin sensitivity through diet and exercise, as this may mimic the metabolic profile associated with the 'longevity genotype' (lower fasting insulin, lower HOMA-IR).
The OR for homozygous minor vs. homozygous major alleles between the cases and controls was 2.75 (P < 0.00009; adjusted P < 0.00135).
Why this rating
Large, homogeneous population, nested case-control design, strong statistical significance, but observational nature limits causal inference.
Source
FOXO3A genotype is strongly associated with human longevity
Bradley J. Willcox et al. · Proceedings of the National Academy of Sciences · 2008
DOI 10.1073/pnas.0801030105
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