Research
Mixed
Switching to a high-fiber, low-fat diet reduces colonic mucosal proliferation and inflammation biomarkers, thereby lowering colon cancer risk.
Adopting a diet high in fiber (especially resistant starch) and low in animal fat and protein can rapidly reduce biological markers of colon cancer risk. This involves shifting away from Western-style diets toward traditional African-style diets rich in plant fibers.
GoodSupportsHIGH confidence
switching African Americans to a high-fibre, low-fat diet for 2 weeks, were associated with a significant reduction in colonic mucosal inflammation and proliferation biomarkers of cancer risk.
Why this rating
Randomized crossover design with close supervision, though short duration (2 weeks) and surrogate endpoints (biomarkers, not cancer incidence).
Source
Fat, fibre and cancer risk in African Americans and rural Africans
Stephen J. O’Keefe et al. · Nature Communications · 2015
crossover · n=40Cited 967×
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