Hormonal
Acute or intermittent administration of the flavonoid fisetin acts as a senolytic to clear senescent cells, thereby reducing age-related pathology and extending both healthspan and lifespan in aged mice.
Fisetin is a potent senolytic that extends healthspan and lifespan in mice when administered intermittently at high doses (e.g., 100 mg/kg body weight for 5 days). While human trials are beginning, current evidence supports an intermittent 'hit-and-run' dosing strategy rather than daily supplementation to maximize efficacy and minimize potential side effects. Consult a physician before starting high-dose supplementation.
Acute or intermittent treatment of progeroid and old mice with fisetin reduced senescence markers in multiple tissues... Administration of fisetin to wild-type mice late in life restored tissue homeostasis, reduced age-related pathology, and extended median and maximum lifespan.
Why this rating
Strong preclinical evidence in multiple mouse models (progeroid and wild-type) and human tissue explants, though human clinical trial data is not yet included in this paper.
Source
Fisetin is a senotherapeutic that extends health and lifespan
Matthew J. Yousefzadeh et al. · EBioMedicine · 2018
DOI 10.1016/j.ebiom.2018.09.015
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