Research

Hormonal

Testosterone administration in eugonadal men produces a dose-dependent increase in fat-free mass, muscle volume, strength, and power, following a single linear dose-response relationship without evidence of receptor saturation at supraphysiological levels.

If you are a healthy young man with normal testosterone, adding exogenous testosterone will increase your muscle mass and strength in direct proportion to the dose, even at levels far above what your body naturally produces. You do not need to train harder or eat more protein than normal to see these gains, as the hormonal driver is the primary factor. However, higher doses bring higher risks for side effects like acne and negative lipid changes.

StrongSupportsVERY_HIGH confidence
We conclude that changes in circulating testosterone concentrations... are associated with testosterone dose- and concentration-dependent changes in fat-free mass, muscle size, strength and power... in conformity with a single linear dose-response relationship.
Shalender Bhasin et al. · American Journal of Physiology-Endocrinology and Metabolism · 2001

Why this rating

Double-blind, randomized, controlled trial with graded doses and standardized nutrition/exercise.

Source

Testosterone dose-response relationships in healthy young men

Shalender Bhasin et al. · American Journal of Physiology-Endocrinology and Metabolism · 2001

rct · n=61Cited 959×
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