Research
Hormonal
Obesity promotes aggressive breast cancer behavior (growth, invasion, metastasis) through a mechanism involving hypoxia-induced inflammation, increased aromatase expression, and stimulation of cancer stem cells.
Weight loss interventions aim to break the cycle of obesity-driven inflammation and estrogen production, thereby reducing the fuel for tumor growth and metastasis.
GoodSupportsHIGH confidence
Obesity increases local and circulating proinflammatory cytokines, which promote tumor angiogenesis and stimulate the most malignant cancer stem cell population to drive cancer growth, invasion, and metastasis.
Why this rating
Based on mechanistic reviews and cellular/molecular studies cited in the paper.
Source
Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention
Manuel Picon‐Ruiz et al. · CA A Cancer Journal for Clinicians · 2017
DOI 10.3322/caac.21405
narrative_reviewCited 951×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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