Hormonal
Lorcaserin (10 mg twice daily) combined with lifestyle modification produces significantly greater weight loss and maintenance compared to placebo in obese or overweight adults over 2 years.
Take 10mg of Lorcaserin twice daily alongside a structured diet and exercise plan. This medication helps reduce food intake by targeting specific serotonin receptors in the brain. It is most effective when combined with a daily caloric deficit of 600 kcal and 30 minutes of moderate exercise. Monitor for common side effects like headache or nausea, which are generally mild.
In conjunction with behavioral modification, lorcaserin was associated with significant weight loss and improved maintenance of weight loss, as compared with placebo.
Why this rating
Large, multicenter, randomized, double-blind, placebo-controlled trial (RCT) with 3182 participants.
Source
Multicenter, Placebo-Controlled Trial of Lorcaserin for Weight Management
Steven R. Smith et al. · New England Journal of Medicine · 2010
DOI 10.1056/nejmoa0909809
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