Research
Hormonal
Adiponectin levels are negatively correlated with liver fat and hepatic insulin resistance, and low levels are associated with more extensive necroinflammation in NAFLD.
Higher levels of the hormone adiponectin are protective against fatty liver and inflammation. Low levels are a sign of worse liver disease and insulin resistance.
GoodSupportsHIGH confidence
Adiponectin levels correlate negatively with liver fat and hepatic IR in diabetic patients and in their healthy relatives. Similarly, low adiponectin levels are associated with increased fat content and more extensive necroinflammation in NAFLD patients.
Why this rating
Cited cross-sectional and cohort studies.
Source
Insulin Resistance: A Metabolic Pathway to Chronic Liver Disease *
Elisabetta Bugianesi et al. · Hepatology · 2005
DOI 10.1002/hep.20920
narrative_reviewCited 889×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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