Hormonal
Increased intramyocellular triglyceride (IMTG) content in insulin-sensitive skeletal muscle (soleus) is a primary determinant of in vivo whole-body insulin resistance in humans, independent of total body fat.
If you are lean but have a family history of type 2 diabetes, you may still have insulin resistance driven by fat stored inside your muscles, not just overall body weight. This internal muscle fat is a stronger predictor of metabolic health than your total body fat percentage. Regular physical activity helps manage this internal lipid storage.
Offspring of diabetic parents... were characterized by insulin resistance and increased intramyocellular triglyceride content in the soleus... Stepwise regression analysis selected intramyocellular triglyceride soleus content and plasma free fatty acid levels as the main predictors of whole body insulin sensitivity.
Why this rating
Controlled clinical study with gold-standard clamp measurements and specific NMR quantification, though observational in nature regarding the lipid-insulin link.
Source
Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents.
Gianluca Perseghin et al. · Diabetes · 1999
DOI 10.2337/diabetes.48.8.1600
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →