Research
Hormonal
Dysregulation of AMPK activity is associated with insulin resistance and the metabolic syndrome in humans.
Maintaining a healthy weight and lifestyle can help keep your AMPK activity optimal, which is crucial for preventing insulin resistance and metabolic syndrome.
GoodSupportsHIGH confidence
The association of decreased AMPK activity and IR has been conclusively demonstrated in the adipose tissue of both very obese individuals undergoing bariatric surgery and patients with Cushing’s syndrome.
Why this rating
Based on human studies showing decreased AMPK activity in insulin-resistant patients.
Source
AMPK, insulin resistance, and the metabolic syndrome
Neil B. Ruderman et al. · Journal of Clinical Investigation · 2013
DOI 10.1172/jci67227
narrative_reviewCited 860×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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