Research
Hormonal
Obesity is associated with an increased risk of coronary heart disease (CHD) mortality, with risk increasing as BMI and waist-to-hip ratio increase.
Maintaining a healthy weight is crucial for preventing heart disease. The risk of dying from coronary heart disease increases significantly as your BMI rises, with those having a BMI of 32 or higher facing nearly six times the risk compared to those with a BMI under 22.
StrongSupportsVERY_HIGH confidence
A relationship between obesity and CHD mortality was demonstrated in the Nurses’ Health Study among women who had never smoked.
Why this rating
Supported by large prospective studies (Nurses' Health Study, Paris Prospective Study).
Source
The Obesity Epidemic: Pathophysiology and Consequences of Obesity
F. Xavier Pi‐Sunyer · Obesity Research · 2002
DOI 10.1038/oby.2002.202
narrative_reviewCited 860×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Abdominal or upper-body obesity is independently associated with a higher risk of developing type 2 diabetes, hypertension, and cardiovascular disease compared to lower-body fat distribution.Strong
- Obesity, particularly abdominal obesity, increases the risk of type 2 diabetes, with risk rising steeply as BMI increases.Strong
- Obesity is associated with an increased risk of hypertension, with risk increasing as BMI and abdominal obesity increase.Strong
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →