Hormonal
Obesity induces a state of chronic low-grade systemic inflammation originating in adipose tissue, driven by macrophage infiltration, altered adipokine secretion (increased leptin, decreased adiponectin), and metabolic stressors like free fatty acids and hypoxia.
Recognize that excess body fat, particularly visceral fat, triggers a biological inflammatory response that can worsen metabolic health. While lifestyle changes like physical activity can help reduce this inflammation, understanding the biological basis of obesity can help reduce stigma and highlight the importance of comprehensive health management beyond just weight loss.
Obesity, like other chronic diseases mentioned earlier, presents an inflammatory component. Indeed, it is now widely agreed that obesity is also a state of low-grade chronic inflammation.
Why this rating
The paper cites multiple large-scale population studies, animal models, and consistent findings across adults and children.
Source
Obesity, inflammation and the immune system
Fátima Pérez de Heredia et al. · Proceedings of The Nutrition Society · 2012
DOI 10.1017/s0029665112000092
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