Hormonal
Activation of AMP-activated protein kinase (AMPK) inhibits NF-κB signaling and suppresses chronic inflammation, thereby improving healthspan and extending lifespan.
To leverage AMPK for longevity and inflammation control, prioritize physical exercise and dietary strategies that naturally activate this pathway, such as consuming phytochemicals (e.g., resveratrol, curcumin) and maintaining energy balance. These lifestyle factors are known physiological inducers of AMPK, which in turn suppresses inflammatory signaling linked to aging and metabolic disease.
AMPK signaling seems to enhance energy metabolism while it can repress inflammatory responses linked to chronic stress, e.g., in nutritional overload and during the aging process.
Why this rating
The paper is a review summarizing multiple in vitro, animal, and some human studies, but lacks a single definitive clinical trial.
Source
AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan
Antero Salminen et al. · Journal of Molecular Medicine · 2011
DOI 10.1007/s00109-011-0748-0
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